SCHEMBL7965745

SCHEMBL7965745

FC(F)(F)c1ccc(NCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)c(C(F)(F)F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ALDH1A1 P00352 4/20 0.34
LMNA P02545 3/20 0.33
HTT P42858 3/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
RHOC P08134 1/20 0.32
RHOA P61586 1/20 0.32
CYP1A2 P05177 2/20 0.32
CYP3A4 P08684 2/20 0.32
CYP2C19 P33261 2/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
POLB P06746 3/20 0.31
PDE3B Q13370 1/20 0.31
PDE3A Q14432 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979279 0.90 MAPT (0.36) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL7982287 0.90 HDAC1 (0.36) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL7979432 0.87 MAPT (0.37) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL7979399 0.87 MAPT (0.34) MAPTSMN1; SMN2RAB9AALDH1A1LMNA
SCHEMBL8408424 0.86 HTT (0.38) SMN1; SMN2ALDH1A1LMNAHTTRHOC
SCHEMBL7976268 0.85 MAPT (0.56) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL8659999 0.83 HTT (0.37) HTTRHOCRHOASCN8ASCN9A
SCHEMBL8631007 0.83 RHOC (0.38) SMN1; SMN2ALDH1A1LMNAHTTRHOC
SCHEMBL7965747 0.83 RHOC (0.42) MAPTNPC1RAB9AHTTGAA
SCHEMBL7073001 0.82 PRKAB2 (0.38) MAPTSMN1; SMN2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed