Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7965989 | 0.86 | ESR1 (0.30) | — | |
| SCHEMBL7965995 | 0.79 | — | — | |
| Malonic Acid SCHEMBL7953260 | 0.74 | MAPT (0.44) | HTR1AABCB1MAPTLMNASMN1; SMN2 | |
| SCHEMBL7965451 | 0.74 | SMN1; SMN2 (0.55) | HTR1AMAPTALDH1A1LMNAGAA | |
| SCHEMBL7967094 | 0.73 | HTR7 (0.54) | HTR1AMAPTALDH1A1LMNATP53 | |
| Succinic Acid SCHEMBL7965777 | 0.73 | ABCB1 (0.48) | HTR1AABCB1MAPTMEN1KMT2A | |
| SCHEMBL7962997 | 0.73 | CYP2D6 (0.50) | HTR1AKMT2A | |
| SCHEMBL7967123 | 0.72 | ABCB1 (0.58) | ABCB1 | |
| SCHEMBL7963099 | 0.71 | KMT2A (0.49) | HTR1AMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7965342 | 0.71 | KMT2A (0.44) | HTR1AABCB1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |