Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | SCN1A | P35498 | 3/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963099 | 0.91 | KMT2A (0.49) | CYP2D6CACNA1GKCNH2HTR1AKMT2A | |
| SCHEMBL7965451 | 0.87 | SMN1; SMN2 (0.55) | CYP2D6HTR1AKMT2AL3MBTL1KDM4E | |
| SCHEMBL7967094 | 0.83 | HTR7 (0.54) | HTR1AKDM4E | |
| SCHEMBL7962999 | 0.82 | OPRL1 (0.40) | HTR1A | |
| SCHEMBL7962994 | 0.82 | DRD2 (0.38) | CYP2D6CACNA1GKCNH2 | |
| Bromide SCHEMBL7965940 | 0.81 | HTR1A (0.38) | SCN1ASCN5ASCN9AHTR1AKMT2A | |
| SCHEMBL7964903 | 0.81 | CYP2D6 (0.51) | CYP2D6CACNA1GKCNH2SCN1ASCN5A | |
| SCHEMBL16783945 | 0.80 | CYP2D6 (0.62) | CYP2D6CACNA1GKCNH2SCN1ASCN5A | |
| SCHEMBL16783943 | 0.80 | CYP2D6 (0.62) | CYP2D6CACNA1GKCNH2SCN1ASCN5A | |
| SCHEMBL16784006 | 0.80 | CYP2D6 (0.62) | CYP2D6CACNA1GKCNH2SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |