Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965338 | 0.84 | OPRM1 (0.31) | DRD4 | |
| SCHEMBL7965345 | 0.83 | SLC6A1 (0.34) | DRD4 | |
| SCHEMBL7969773 | 0.83 | ABCB1 (0.47) | KMT2ALMNAMEN1SMN1; SMN2MAPT | |
| Succinic Acid SCHEMBL7965777 | 0.80 | ABCB1 (0.48) | KMT2AMEN1MAPTABCB1TDP1 | |
| SCHEMBL7965451 | 0.80 | SMN1; SMN2 (0.55) | KMT2ALMNAMEN1SMN1; SMN2MAPT | |
| SCHEMBL7967123 | 0.79 | ABCB1 (0.58) | ABCB1 | |
| SCHEMBL7965741 | 0.78 | HTR1A (0.54) | CYP1A2CYP2C19HTR1A | |
| SCHEMBL7963266 | 0.77 | SMN1; SMN2 (0.39) | KMT2ALMNAMEN1SMN1; SMN2MAPT | |
| Malonic Acid SCHEMBL7953260 | 0.77 | MAPT (0.44) | LMNASMN1; SMN2MAPTABCB1HTR1A | |
| SCHEMBL7963099 | 0.77 | KMT2A (0.49) | KMT2AMEN1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |