Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871828 | 0.88 | HTR1A (0.72) | HTR1ASLC6A4 | |
| SCHEMBL7881145 | 0.88 | HTR1A (0.72) | HTR1ASLC6A4 | |
| SCHEMBL7966964 | 0.86 | HTR1A (0.65) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7882931 | 0.85 | HTR1A (0.70) | HTR1ASLC6A4 | |
| SCHEMBL7965634 | 0.84 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7966021 | 0.84 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7953370 | 0.83 | HTR1A (0.56) | HTR1ASLC6A4ADRB2ADRB1ADRB3 | |
| SCHEMBL7966017 | 0.83 | HTR1A (0.46) | HTR1ASLC6A4 | |
| SCHEMBL7965929 | 0.82 | HTR1A (0.62) | HTR1ASLC6A4 | |
| SCHEMBL7964959 | 0.82 | HTR1A (0.69) | HTR1ASLC6A4ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |