Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876375 | 0.87 | HTR1A (0.51) | HTR1ASLC6A4DRD4HRH3 | |
| SCHEMBL7966021 | 0.85 | HTR1A (0.47) | HTR1ASLC6A4 | |
| SCHEMBL7966017 | 0.84 | HTR1A (0.46) | HTR1ASLC6A4 | |
| SCHEMBL7966018 | 0.84 | HTR1A (0.68) | HTR1ASLC6A4 | |
| SCHEMBL7884092 | 0.84 | HTR1A (0.51) | HTR1ASLC6A4HRH3 | |
| SCHEMBL7881284 | 0.83 | HRH3 (0.52) | HTR1ASLC6A4HRH3 | |
| SCHEMBL7963898 | 0.82 | CHRNA7 (0.43) | HTR1ASLC6A4DRD4HRH3 | |
| SCHEMBL7885417 | 0.82 | HTR1A (0.54) | HTR1ASLC6A4 | |
| SCHEMBL7963782 | 0.80 | HTR1A (0.47) | HTR1ASLC6A4DRD4HRH3 | |
| SCHEMBL7967101 | 0.80 | HTR1A (0.40) | HTR1ASLC6A4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |