Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 8/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.39 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954749 | 0.87 | PKN1 (0.49) | PKN1PKN2RIPK1ADORA3CCNT1 | |
| SCHEMBL7964827 | 0.84 | CHRM2 (0.52) | PKN1PKN2RIPK1ADORA3CCNT1 | |
| SCHEMBL7016736 | 0.81 | PKN1 (0.46) | PKN1PKN2RIPK1ADORA3CCNT1 | |
| SCHEMBL7477180 | 0.81 | RIPK1 (0.46) | PKN1PKN2RIPK1ADORA3CCNT1 | |
| SCHEMBL8601355 | 0.77 | PKN1 (0.55) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL4504445 | 0.75 | PIM1 (0.47) | PKN1PKN2ADORA3PIM1GAA | |
| SCHEMBL11020624 | 0.74 | PKN1 (0.49) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL15228495 | 0.74 | PKN1 (0.55) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL7486053 | 0.73 | PKN1 (0.50) | PKN1PKN2ADORA3GAAMGAM | |
| SCHEMBL1013853 | 0.73 | LMNA (0.54) | PKN1PKN2ADORA3GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |