Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966279 | 1.00 | MMP1 (0.37) | MMP1MMP9MMP13CYP3A4CYP3A5 | |
| SCHEMBL7966628 | 0.86 | CA2 (0.47) | MMP1MMP9MMP13ADAMTS4TBXAS1 | |
| SCHEMBL7966630 | 0.86 | CA2 (0.47) | MMP1MMP9MMP13ADAMTS4TBXAS1 | |
| SCHEMBL7979922 | 0.86 | PTAFR (0.43) | ADAMTS4HTTSMN1; SMN2NAMPTPTAFR | |
| SCHEMBL7976660 | 0.86 | PTAFR (0.43) | ADAMTS4HTTSMN1; SMN2NAMPTPTAFR | |
| SCHEMBL7976664 | 0.86 | PTAFR (0.43) | ADAMTS4HTTSMN1; SMN2NAMPTPTAFR | |
| SCHEMBL7979925 | 0.81 | CYP3A4 (0.39) | CYP3A4ADAMTS4HTTSMN1; SMN2NAMPT | |
| SCHEMBL7979929 | 0.81 | CYP3A4 (0.39) | CYP3A4ADAMTS4HTTSMN1; SMN2NAMPT | |
| SCHEMBL7976666 | 0.81 | CYP3A4 (0.39) | MMP1MMP9MMP13CYP3A4ADAMTS4 | |
| SCHEMBL7983302 | 0.81 | CYP3A4 (0.39) | CYP3A4ADAMTS4HTTSMN1; SMN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |