Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130734 | 0.81 | LMNA (0.48) | LMNAL3MBTL1KCNH2HTR1AHTR2C | |
| SCHEMBL7964589 | 0.79 | LMNA (0.51) | LMNAL3MBTL1KCNH2HTR1AHTR2C | |
| SCHEMBL7855826 | 0.77 | LMNA (0.59) | LMNAL3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL31270697 | 0.75 | LMNA (0.74) | LMNAL3MBTL1KCNH2HTR1AHTR2C | |
| SCHEMBL1844592 | 0.74 | LMNA (0.49) | LMNAL3MBTL1 | |
| SCHEMBL6410513 | 0.74 | CACNA1H (0.39) | CACNA1HCACNA1GCACNA1IPDE2ACYP11B1 | |
| SCHEMBL8221199 | 0.74 | NSD2 (0.41) | KCNH2CACNA1HCACNA1GCACNA1ITRPV4 | |
| SCHEMBL6417191 | 0.74 | CACNA1H (0.38) | CACNA1HCACNA1GCACNA1ITRPV4PDE2A | |
| SCHEMBL7970784 | 0.74 | FNTA (0.65) | LMNAL3MBTL1KCNH2 | |
| SCHEMBL3500590 | 0.74 | FNTA (0.65) | LMNAL3MBTL1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333335-B1 | TO INHIBIT PRENYL-PROTEIN TRANSFERASE AND THE PRENYLATION OF THE ONCOGENE PROTEIN RAS | MERCK & CO., INC. | 2001-12-25 | — | — | US | disclosed |
| WO-2001007046-A1 | PRENYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 2001-02-01 | — | — | WO | disclosed |