Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PTAFR | P25105 | 4/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978598 | 1.00 | MMP12 (0.47) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7966621 | 1.00 | MMP12 (0.47) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7980127 | 1.00 | MMP12 (0.47) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7980395 | 1.00 | MMP12 (0.47) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7979918 | 0.90 | MMP13 (0.43) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7979913 | 0.90 | MMP13 (0.43) | MMP12MMP13PDK1CYP3A4CYP2C19 | |
| SCHEMBL7822509 | 0.90 | CYP11B2 (0.38) | MMP12MMP13CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7822506 | 0.90 | CYP11B2 (0.38) | MMP12MMP13CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL7976679 | 0.87 | CYP19A1 (0.42) | ALDH1A1HPGDPTAFRCYP11B2CYP11B1 | |
| SCHEMBL8020645 | 0.87 | CYP19A1 (0.42) | ALDH1A1HPGDPTAFRCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |