Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345676 | 0.90 | KMT2A (0.43) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7966271 | 0.90 | AVPR2 (0.42) | KMT2AMEN1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7338964 | 0.89 | KMT2A (0.43) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7780674 | 0.89 | KMT2A (0.42) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7335732 | 0.86 | ALDH1A1 (0.43) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7424282 | 0.86 | AVPR2 (0.49) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7342854 | 0.86 | NPC1 (0.43) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7336940 | 0.86 | LMNA (0.41) | HPGDKMT2AALDH1A1AVPR2AVPR1A | |
| SCHEMBL7345034 | 0.86 | AVPR2 (0.40) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8662244 | 0.85 | AVPR2 (0.47) | HPGDKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |