Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7482761 | 0.99 | MAPT (0.35) | MAPTALDH1A1KMT2ALMNAMAPK1 | |
| SCHEMBL7966890 | 0.92 | AVPR2 (0.39) | MAPTALDH1A1KDM4ECYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL7964351 | 0.92 | AVPR2 (0.38) | MAPTALDH1A1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7478471 | 0.91 | MAP3K7 (0.36) | KMT2AMAP3K7CYP3A4MEN1ABCB1 | |
| SCHEMBL7342762 | 0.86 | AVPR2 (0.41) | MAPTALDH1A1CYP1A2CYP3A4EGFR | |
| SCHEMBL7966897 | 0.85 | ALDH1A1 (0.34) | MAPTALDH1A1KMT2ALMNAMAPK1 | |
| SCHEMBL7968552 | 0.85 | HDAC8 (0.41) | MAPTKMT2ALMNAMAP3K7MEN1 | |
| SCHEMBL7597522 | 0.85 | MAP3K7 (0.36) | MAP3K7ABCB1AVPR2AVPR1AAVPR1B | |
| SCHEMBL7975461 | 0.84 | MAP3K7 (0.37) | MAPTMAP3K7ABCB1AVPR2AVPR1A | |
| Hydrochloric Acid SCHEMBL7971982 | 0.84 | MAP3K7 (0.37) | MAPTLMNAMAP3K7EGFRAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |