Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237364 | 0.78 | MAPK14 (0.47) | DRD2HTR2AMAPK14CYP1A2ACHE | |
| SCHEMBL461287 | 0.77 | ACHE (0.61) | DRD2HTR2AACHESLC6A4 | |
| SCHEMBL3523366 | 0.77 | MAPK14 (0.47) | DRD2MAPK14CYP1A2ACHESLC6A4 | |
| SCHEMBL470707 | 0.77 | MAPK14 (0.52) | DRD2HTR2AMAPK14CYP1A2ACHE | |
| SCHEMBL7966100 | 0.77 | MAPK14 (0.47) | DRD2HTR2AMAPK14CYP1A2ACHE | |
| SCHEMBL15487431 | 0.77 | MAPK14 (0.49) | DRD2MAPK14ACHESLC6A4 | |
| SCHEMBL1545681 | 0.77 | MAPK14 (0.47) | DRD2HTR2AMAPK14ACHESLC6A4 | |
| Hydrochloric Acid SCHEMBL15486032 | 0.76 | MAPK14 (0.48) | DRD2MAPK14ACHESLC6A4 | |
| Hydrochloric Acid SCHEMBL607480 | 0.76 | MAPK14 (0.46) | HTR2AMAPK14ACHERAB9A | |
| Hydrochloric Acid SCHEMBL531052 | 0.76 | ACHE (0.60) | DRD2HTR2AACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |