Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 7/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968309 | 0.92 | ADRA1D (0.40) | ADRA1DADRA1AADRA1BADAM17CHRM4 | |
| SCHEMBL7968302 | 0.92 | ADRA1D (0.40) | ADRA1DADRA1AADRA1BADAM17CHRM4 | |
| SCHEMBL7954991 | 0.79 | ADRA1D (0.39) | ADRA1DADRA1AADRA1BADAM17MTOR | |
| SCHEMBL7954985 | 0.79 | ADRA1D (0.39) | ADRA1DADRA1AADRA1BADAM17MTOR | |
| SCHEMBL13651261 | 0.77 | ADRA1A (0.46) | ADRA1DADRA1AADRA1BKDM1ACHRM2 | |
| SCHEMBL7967658 | 0.74 | ADRA1D (0.65) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7968307 | 0.74 | ADRA1A (0.39) | ADRA1DADRA1AADRA1BADAM17MTOR | |
| SCHEMBL8129674 | 0.73 | ADRA1A (0.40) | ADRA1DADRA1AADRA1BADAM17MTOR | |
| SCHEMBL8063243 | 0.72 | ADRA1D (0.44) | ADRA1DADRA1AADRA1B | |
| SCHEMBL7965725 | 0.71 | ADRA1D (0.64) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214832-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-04-10 | — | — | US | disclosed |
| EP-1003512-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1998057642-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |