Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GPR6 | P46095 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425044 | 0.90 | DRD2 (0.46) | KMT2AMEN1KDM4ESMN1; SMN2HSD11B1 | |
| SCHEMBL7422014 | 0.89 | SMN1; SMN2 (0.47) | KMT2AMEN1SMN1; SMN2HSD11B1NPC1 | |
| SCHEMBL7423134 | 0.86 | PTPN1 (0.51) | KMT2AMEN1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL7418271 | 0.85 | KMT2A (0.47) | KMT2AMEN1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL7967067 | 0.83 | ALDH1A1 (0.55) | KMT2AMEN1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL7376664 | 0.80 | CYP1A2 (0.45) | KMT2AMEN1SMN1; SMN2HSD11B1RAB9A | |
| SCHEMBL7378235 | 0.79 | GPBAR1 (0.45) | KMT2AMEN1SMN1; SMN2HSD11B1ALDH1A1 | |
| SCHEMBL7419515 | 0.77 | DRD2 (0.45) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7423123 | 0.76 | ALDH1A1 (0.55) | KMT2AMEN1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL7430332 | 0.76 | MAPT (0.46) | KMT2AMEN1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |