Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006034 | 0.89 | PLA2G7 (0.69) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL30839727 | 0.88 | CYP3A4 (0.65) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL302092 | 0.88 | CYP3A4 (0.65) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL6011528 | 0.87 | PLA2G7 (0.61) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| Hydrochloric Acid SCHEMBL5800872 | 0.85 | CYP3A4 (0.62) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| Hydrochloric Acid SCHEMBL7531143 | 0.85 | CYP3A4 (0.62) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL5684596 | 0.85 | PLA2G7 (0.59) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL27186003 | 0.84 | CYP3A4 (0.61) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| SCHEMBL31661394 | 0.84 | CYP3A4 (0.61) | PLA2G7CYP3A4TSHRNFKB1PMP22 | |
| Hydrochloric Acid SCHEMBL5685502 | 0.84 | PLA2G7 (0.58) | PLA2G7CYP3A4TSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964635-B1 | ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-05-02 | — | — | EP | disclosed |
| US-9693997-B2 | Antiviral compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9693997-B2 | Antiviral compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9693997-B2 | Antiviral compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160000760-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-01-07 | — | — | US | disclosed |
| US-20160000760-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-01-07 | — | — | US | disclosed |
| US-20160000760-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-01-07 | — | — | US | disclosed |
| WO-2014135495-A1 | ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-12 | — | — | WO | disclosed |
| US-6248197-B1 | Method for producing a shaped multifilament, non-thermoplastic, elastomeric yarn | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-06-19 | — | — | US | disclosed |
| US-5145790-A | Immunoassay, fluorescein derivative | ABBOTT LABORATORIES (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0455058-A2 | Reagents and method for detecting polychlorinated biphenyls | ABBOTT LABORATORIES (US) | 1991-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160000760-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | PLA2G7 527/4885CYP3A4 241/4885TSHR 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.