Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969208 | 1.00 | CACNA1G (0.47) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL15271240 | 0.85 | GPR119 (0.44) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL15289827 | 0.85 | GPR119 (0.44) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL26134495 | 0.84 | ALDH1A1 (0.47) | HDAC1HDAC6TP53KMT2AALDH1A1 | |
| SCHEMBL8572892 | 0.82 | KLK7 (0.43) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL8572897 | 0.82 | KLK7 (0.43) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL10841922 | 0.81 | HDAC1 (0.41) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL28546762 | 0.81 | GPR119 (0.43) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL22536521 | 0.81 | CACNA1G (0.49) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 | |
| SCHEMBL29277630 | 0.81 | CACNA1G (0.49) | CACNA1GCACNA1HCACNA1IKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0968201-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998035951-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-20 | — | — | WO | disclosed |