Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 7/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR2B | P41595 | 3/20 | 0.58 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969393 | 1.00 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2BSLC9A1 | |
| SCHEMBL9386089 | 0.86 | ALOX5 (0.58) | ALOX5HTR2CHTR2AHTR2BSLC9A1 | |
| SCHEMBL9386086 | 0.86 | ALOX5 (0.58) | ALOX5HTR2CHTR2AHTR2BSLC9A1 | |
| SCHEMBL7970862 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2BGPR88 | |
| SCHEMBL7973024 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2BDRD4 | |
| SCHEMBL7969491 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL7973022 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2BDRD4 | |
| SCHEMBL7969487 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2B | |
| SCHEMBL7970860 | 0.84 | ALOX5 (0.66) | ALOX5HTR2CHTR2AHTR2BGPR88 | |
| SCHEMBL9379914 | 0.83 | ALOX5 (0.83) | ALOX5HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |