Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.66 |
| ▸ | HTR2A | P28223 | 7/20 | 0.57 |
| ▸ | HTR2C | P28335 | 7/20 | 0.57 |
| ▸ | HTR2B | P41595 | 7/20 | 0.57 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969491 | 1.00 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL7970862 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7970860 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7969393 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL7973022 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7973024 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL7969398 | 0.84 | ALOX5 (0.66) | ALOX5HTR2AHTR2CHTR2B | |
| SCHEMBL7969812 | 0.83 | ALOX5 (0.62) | ALOX5HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL7969809 | 0.83 | ALOX5 (0.62) | ALOX5HTR2AHTR2CHTR2BKDM1A | |
| SCHEMBL7971315 | 0.83 | ALOX5 (0.71) | ALOX5HTR2AHTR2CHTR2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | claimed |
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0436199-B1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LAB (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5120752-A | N-(1-(20(3-pyridyloxy)phenyl)cyclopropyl) alkyl-N-hydroxyurea compounds, antiinflammatory agents | ABBOTT LABORATORIES (US) | 1992-06-09 | — | — | US | disclosed |
| US-5037853-A | Antiinflammatory agents | ABBOTT LABORATORIES (US) | 1991-08-06 | — | — | US | disclosed |
| EP-0436199-A1 | Cyclopropyl derivative lipoxygenase inhibitors | ABBOTT LABORATORIES (US) | 1991-07-10 | — | — | EP | disclosed |