Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | HTR6 | P50406 | 6/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970608 | 0.85 | SRC (0.50) | SRCHTR6PDE4APDE4BPDE4C | |
| SCHEMBL28052552 | 0.77 | ALDH1A1 (0.52) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25748059 | 0.76 | HTR6 (0.60) | SRCHTR6PDE4APDE4BPDE4C | |
| SCHEMBL17927644 | 0.76 | HTR6 (0.41) | SRCHTR6PDE4APDE4BPDE4C | |
| SCHEMBL7970600 | 0.75 | POLB (0.38) | SRCPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7969684 | 0.75 | SRC (1.00) | SRCHTR6NOD1 | |
| SCHEMBL20840619 | 0.74 | HTR6 (0.68) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12675368 | 0.73 | SRC (0.63) | SRCHTR6NOD1 | |
| SCHEMBL10141904 | 0.72 | SRC (0.56) | SRCHTR6GAA | |
| SCHEMBL25422879 | 0.72 | MTNR1B (0.55) | SRCHTR6PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |