Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | HTR6 | P50406 | 8/20 | 0.54 |
| ▸ | FABP3 | P05413 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27885302 | 0.81 | HTR6 (0.50) | SRCHTR6SLC9A1AGTR1LMNA | |
| SCHEMBL12093313 | 0.81 | HTR6 (0.70) | SRCHTR6FABP3FABP4FABP5 | |
| SCHEMBL5376311 | 0.76 | MTNR1B (0.45) | SRCHTR6FABP3FABP4FABP5 | |
| SCHEMBL27902317 | 0.76 | HTR6 (0.44) | SRCHTR6SLC9A1AGTR1 | |
| SCHEMBL7969684 | 0.73 | SRC (1.00) | SRCHTR6CXCL8NOD1PSEN1 | |
| SCHEMBL3564084 | 0.73 | SRC (0.51) | SRCHTR6FABP3FABP4FABP5 | |
| SCHEMBL3557485 | 0.72 | AGTR1 (0.58) | SRCHTR6FABP3FABP4FABP5 | |
| SCHEMBL25540657 | 0.71 | AGTR1 (0.50) | HTR6SLC9A1AGTR1HTTSMN1; SMN2 | |
| SCHEMBL14732395 | 0.71 | HTR6 (0.46) | SRCHTR6FABP3FABP4FABP5 | |
| SCHEMBL5758119 | 0.70 | HTR6 (1.00) | HTR6HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | claimed |
| CN-1266131-C | Process for the preparation of heterocgclic indene analogs | HOFFMANN LA ROCHE (CH) | 2006-07-26 | — | — | CN | claimed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | claimed |
| CN-1487922-A | Process for preparing heterocyclic indene analogs | 弗・哈夫曼-拉罗切有限公司 | 2004-04-07 | — | — | CN | claimed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | claimed |
| US-7169935-B2 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. (US) | 2007-01-30 | — | — | US | disclosed |
| CN-1266131-C | Process for the preparation of heterocgclic indene analogs | HOFFMANN LA ROCHE (CH) | 2006-07-26 | — | — | CN | disclosed |
| US-6777559-B2 | CYCLOCARBONYLATING ACETIC ACID (OR BENZOIC ACID)-1-(1-BENZENESULFONYL-1H-INDOL-2-YL)-ALLYL ESTER TO OBTAIN 9-BENZENESULFONYL-9H-CARBAZOL-4-YL ESTER; SAPONIFYING | HOFFMANN-LA ROCHE INC. | 2004-08-17 | — | — | US | disclosed |
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | SCALONE MICHELANGELO (CH) | 2004-07-01 | — | — | US | disclosed |
| CN-1487922-A | Process for preparing heterocyclic indene analogs | 弗・哈夫曼-拉罗切有限公司 | 2004-04-07 | — | — | CN | disclosed |
| EP-1355880-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | HOFFMANN-LA ROCHE INC. | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127723-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | SRC 1343/4885HTR6 3297/4885FABP3 4536/4885 |
| US-20020099223-A1 | Process for preparing heterocyclic indene analogs | CYP3A4, CYP8B1, CYP51A1 | SRC 1343/4885HTR6 3297/4885FABP3 4536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.