Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21065308 | 0.83 | KDM1A (0.44) | KDM1ARCOR1 | |
| SCHEMBL21065268 | 0.81 | ESR2 (0.41) | TSHR | |
| SCHEMBL31154384 | 0.81 | MGLL (0.40) | KDM1ARCOR1HTR2CP2RY14 | |
| SCHEMBL21065262 | 0.78 | ALDH1A1 (0.43) | TSHR | |
| SCHEMBL28532293 | 0.72 | KDM1A (0.41) | KDM1ARCOR1HTR2CGPBAR1P2RY14 | |
| SCHEMBL31154403 | 0.70 | CCR2 (0.37) | — | |
| SCHEMBL31154393 | 0.70 | CCR2 (0.37) | — | |
| SCHEMBL18627834 | 0.70 | KDM1A (0.41) | KDM1ARCOR1GPBAR1TSHR | |
| SCHEMBL38656819 | 0.68 | NOTUM (0.49) | HTR2CP2RY14 | |
| SCHEMBL19403587 | 0.68 | KDM1A (0.44) | KDM1ARCOR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291520-B1 | INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES | PFIZER | 2001-09-18 | — | — | US | disclosed |
| EP-0559743-B1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0559743-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. | PFIZER HOSPITAL PROD (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1992009566-A1 | NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE | PFIZER INC. (US) | 1992-06-11 | — | — | WO | disclosed |