Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | FAAH | O00519 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 5/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7869518 | 0.85 | DRD2 (1.00) | DRD2DRD4FAAHDRD3CNR1 | |
| SCHEMBL27966706 | 0.85 | DRD2 (1.00) | DRD2DRD4FAAHDRD3CNR1 | |
| SCHEMBL17865091 | 0.84 | DRD2 (0.72) | DRD2DRD4FAAHDRD3CNR1 | |
| SCHEMBL7966008 | 0.84 | DRD2 (0.72) | DRD2SIGMAR1DRD4DRD3 | |
| SCHEMBL24257354 | 0.83 | DRD2 (0.66) | DRD2SIGMAR1DRD4 | |
| SCHEMBL13922058 | 0.82 | DRD2 (1.00) | DRD2DRD4FAAHDRD3 | |
| SCHEMBL8254760 | 0.81 | DRD2 (0.64) | DRD2SIGMAR1 | |
| SCHEMBL30741699 | 0.81 | DRD2 (0.60) | DRD2SIGMAR1DRD4 | |
| SCHEMBL12501782 | 0.80 | DRD2 (0.65) | DRD2SIGMAR1DRD4DRD3 | |
| SCHEMBL19734921 | 0.80 | SIGMAR1 (0.68) | DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274583-B1 | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. | 2001-08-14 | — | — | US | disclosed |
| US-5977115-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0833637-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0833637-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040136-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |