Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969846 | 0.84 | DRD2 (0.74) | DRD2SIGMAR1DRD3DRD4 | |
| SCHEMBL7662199 | 0.84 | DRD2 (0.54) | DRD2SIGMAR1DRD4 | |
| SCHEMBL27966706 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL7869518 | 0.83 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL17865091 | 0.83 | DRD2 (0.72) | DRD2DRD3DRD4 | |
| SCHEMBL7702063 | 0.83 | ADRA1A (0.55) | DRD2 | |
| SCHEMBL7711219 | 0.80 | DRD2 (0.48) | DRD2DRD3DRD4 | |
| SCHEMBL13922058 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL7596111 | 0.80 | ADRA1D (0.56) | DRD2DRD3DRD4 | |
| SCHEMBL8254760 | 0.79 | DRD2 (0.64) | DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274583-B1 | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. | 2001-08-14 | — | — | US | disclosed |
| US-5977115-A | Alpha 1a adrenergic receptor antagonists | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |