Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 8/20 | 0.61 |
| ▸ | DRD2 | P14416 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL238334 | 0.90 | MEN1 (0.66) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL19066024 | 0.89 | MEN1 (0.65) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4827185 | 0.88 | MEN1 (0.71) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL6042349 | 0.87 | SIGMAR1 (0.59) | MEN1KMT2AGAAHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6288085 | 0.87 | MEN1 (0.69) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7963190 | 0.86 | MEN1 (0.53) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7970649 | 0.83 | MEN1 (0.48) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL2471217 | 0.83 | KMT2A (0.58) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7964854 | 0.83 | GAA (0.52) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7963874 | 0.82 | MEN1 (0.47) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |