Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 9/20 | 0.52 |
| ▸ | DRD2 | P14416 | 6/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042349 | 0.91 | SIGMAR1 (0.59) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL2395803 | 0.88 | LMNA (0.60) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL7969931 | 0.86 | MEN1 (0.65) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL7964854 | 0.86 | GAA (0.52) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL6264412 | 0.82 | HTR1A (0.57) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL6585625 | 0.82 | DRD4 (0.63) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL2395932 | 0.82 | DRD4 (0.67) | DRD4DRD2SIGMAR1DRD3HDAC4 | |
| SCHEMBL11437532 | 0.82 | DRD2 (0.55) | DRD4DRD2SIGMAR1DRD3HTR6 | |
| SCHEMBL238334 | 0.80 | MEN1 (0.66) | MEN1KMT2ADRD4DRD2SIGMAR1 | |
| SCHEMBL7970649 | 0.79 | MEN1 (0.48) | MEN1KMT2ADRD4DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |