Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970649 | 0.84 | MEN1 (0.48) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL7969931 | 0.82 | MEN1 (0.65) | MEN1KMT2ADRD2DRD4KDM4E | |
| SCHEMBL6042349 | 0.82 | SIGMAR1 (0.59) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL7963190 | 0.79 | MEN1 (0.53) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL7964854 | 0.78 | GAA (0.52) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL8672493 | 0.77 | HTR6 (0.42) | DRD2DRD4HDAC4NAMPTKDM4E | |
| SCHEMBL1470365 | 0.75 | DRD4 (0.52) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL238334 | 0.75 | MEN1 (0.66) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL6585625 | 0.74 | DRD4 (0.63) | MEN1KMT2ADRD2DRD4HDAC4 | |
| SCHEMBL2395932 | 0.74 | DRD4 (0.67) | DRD2DRD4HDAC4NAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |