Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969978 | 0.84 | CTRB1 (0.46) | CTRB1KMT2AMEN1DDB1CRBN | |
| SCHEMBL7991029 | 0.84 | CTRB1 (0.46) | CTRB1KMT2AMEN1DDB1CRBN | |
| SCHEMBL6844052 | 0.84 | CTRB1 (0.46) | CTRB1KMT2AMEN1DDB1CRBN | |
| SCHEMBL8088303 | 0.80 | GAA (0.53) | KMT2AMEN1TSHRLMNAALDH1A1 | |
| SCHEMBL3534373 | 0.74 | DDB1 (0.47) | CTRB1KMT2ATSHRDDB1CRBN | |
| SCHEMBL6781853 | 0.73 | MAPT (0.41) | KMT2AMEN1TSHRDDB1CRBN | |
| SCHEMBL6781847 | 0.73 | MAPT (0.41) | KMT2ATSHRLMNAALDH1A1SLC6A3 | |
| SCHEMBL6776703 | 0.73 | MAPT (0.41) | CTRB1KMT2ATSHRDDB1CRBN | |
| SCHEMBL11548049 | 0.70 | DDB1 (0.47) | CTRB1KMT2ATSHRDDB1CRBN | |
| SCHEMBL7501162 | 0.70 | CYP19A1 (0.45) | KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218406-B1 | AS ANTITUMOR AND ANTILEUKEMIC AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-04-17 | — | — | US | disclosed |
| US-6124465-A | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments | RHONE-POULENC S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
| US-6013662-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 2000-01-11 | — | — | US | disclosed |