Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 9/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981259 | 0.85 | ADRB2 (0.46) | KDM1ADRD2IGF1RALOX15 | |
| SCHEMBL7970224 | 0.81 | CYP19A1 (0.41) | — | |
| SCHEMBL9367629 | 0.81 | IGF1R (0.46) | KDM1ADRD2DRD4ESR1ESR2 | |
| SCHEMBL2611809 | 0.73 | ESR1 (0.44) | KDM1ADRD2DRD4ESR1ESR2 | |
| SCHEMBL25471931 | 0.65 | IGF1R (0.47) | KDM1ADRD2DRD4IGF1RALOX15 | |
| SCHEMBL16539039 | 0.64 | CAPN1 (0.47) | KDM1ADRD2DRD4ESR1ESR2 | |
| SCHEMBL23551067 | 0.64 | BCL2 (0.42) | DRD2IGF1RALOX15MAPT | |
| SCHEMBL22012833 | 0.61 | ESR1 (0.48) | ESR1ESR2ALOX15CAPN1KDM4E | |
| SCHEMBL14734507 | 0.61 | GRIN2B (0.49) | ESR1ESR2 | |
| SCHEMBL16902819 | 0.61 | GRIN2B (0.49) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |