Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980288 | 0.86 | KCNH2 (0.47) | KCNH2MAPTALDH1A1HSD17B10KDM4C | |
| SCHEMBL7983806 | 0.77 | PDE10A (0.40) | MAPTALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL1818592 | 0.74 | RAB9A (0.43) | MAPTALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL3918548 | 0.73 | HTR2A (0.54) | MAPTALDH1A1HSD17B10MEN1HPGD | |
| Hydrochloric Acid SCHEMBL1819160 | 0.72 | NPC1 (0.42) | MAPTALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| Bromide SCHEMBL1822835 | 0.72 | NPC1 (0.42) | MAPTALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| Fluoride Ion SCHEMBL1819483 | 0.72 | NPC1 (0.42) | MAPTALDH1A1HSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL30779227 | 0.70 | HTR2A (0.40) | MAPTALDH1A1HSD17B10MEN1HPGD | |
| Ammonia Solution, Strong SCHEMBL27746302 | 0.70 | HTR2A (0.37) | MAPT | |
| SCHEMBL27897683 | 0.69 | LTA4H (0.48) | MAPTSMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |