Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970093 | 0.77 | KCNH2 (0.42) | RAB9ANPC1MAPTSMN1; SMN2FABP5 | |
| SCHEMBL7983255 | 0.77 | LOXL2 (0.39) | LOXL2RAB9ANPC1TP53MAPT | |
| SCHEMBL7983609 | 0.75 | PDE10A (0.47) | PDE10AGAKRIPK2COQ8ANLK | |
| SCHEMBL27369081 | 0.70 | GAK (0.50) | GAKRIPK2COQ8ANLKAAK1 | |
| Hydrochloric Acid SCHEMBL1819160 | 0.68 | NPC1 (0.42) | RAB9ANPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1818592 | 0.66 | RAB9A (0.43) | RAB9ANPC1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL11819246 | 0.66 | PDE10A (0.56) | PDE10ARAB9AMAPTSMN1; SMN2PDE4A | |
| SCHEMBL7980288 | 0.65 | KCNH2 (0.47) | MAPTSMN1; SMN2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL828159 | 0.65 | GAK (0.55) | PDE10AGAKRIPK2COQ8ANLK | |
| Bromide SCHEMBL1822835 | 0.65 | NPC1 (0.42) | RAB9ANPC1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |