Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | S100B | P04271 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980269 | 0.81 | CYP19A1 (0.43) | POLBTSHRMAPK1SMN1; SMN2TP53 | |
| SCHEMBL7984590 | 0.76 | PRKDC (0.36) | TSHRMAPK1PDE3BPDE3ATP53 | |
| SCHEMBL7983553 | 0.72 | S100B (0.44) | PDE3BPDE3ASMN1; SMN2MAOAS100B | |
| SCHEMBL7983756 | 0.71 | SRC (0.55) | SRC | |
| SCHEMBL29368836 | 0.67 | CYP3A4 (0.53) | TSHRPDE3BPDE3ASMN1; SMN2MAOA | |
| SCHEMBL1711296 | 0.67 | CYP3A4 (0.53) | TSHRPDE3BPDE3ASMN1; SMN2MAOA | |
| SCHEMBL9796630 | 0.65 | TP53 (0.41) | POLBSMN1; SMN2TP53KDM4EALDH1A1 | |
| SCHEMBL15218462 | 0.64 | TSPO (0.40) | SMN1; SMN2 | |
| SCHEMBL7980611 | 0.63 | SRC (0.60) | TSHRMAPK1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31195736 | 0.63 | MEN1 (0.41) | TSHRTP53KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |