Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980612 | 0.93 | MCL1 (0.37) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL7987895 | 0.89 | HNF4A (0.38) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL5735372 | 0.89 | RARB (0.52) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL5737152 | 0.86 | FFAR1 (0.48) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL6425907 | 0.83 | ACACB (0.41) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL5735670 | 0.83 | SMN1; SMN2 (0.45) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL5735734 | 0.82 | GABRA1 (0.33) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL5737804 | 0.82 | OPRM1 (0.34) | ALDH1A1 | |
| SCHEMBL7980771 | 0.81 | RARB (0.38) | RARBRARARARGCYP26A1CYP3A4 | |
| SCHEMBL7984067 | 0.80 | RARB (0.36) | RARBRARARARGCYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |