Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | USP8 | P40818 | 1/20 | 0.49 |
| ▸ | USP7 | Q93009 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786089 | 0.82 | RAB9A (0.87) | RAB9ASMN1; SMN2NPC1USP8USP7 | |
| SCHEMBL12253692 | 0.79 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1USP8USP7 | |
| SCHEMBL496978 | 0.79 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1USP8USP7 | |
| SCHEMBL19456389 | 0.78 | NPC1 (0.62) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL30475405 | 0.77 | RAB9A (0.61) | RAB9ASMN1; SMN2NPC1USP8USP7 | |
| SCHEMBL28872388 | 0.77 | RAB9A (0.61) | RAB9ASMN1; SMN2NPC1USP8USP7 | |
| SCHEMBL3899483 | 0.76 | CA1 (0.54) | USP8USP7ALDH1A1KDM4EKMT2A | |
| SCHEMBL28575367 | 0.76 | CA1 (0.54) | USP8USP7ALDH1A1KDM4EKMT2A | |
| SCHEMBL19450184 | 0.75 | NPC1 (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL28872293 | 0.74 | RAB9A (0.59) | RAB9ASMN1; SMN2NPC1USP8USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |