SCHEMBL7970855

SCHEMBL7970855

CCOC(=O)C1CC(c2ccco2)C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.52
ADORA2B P29275 8/20 0.50
ALDH1A1 P00352 6/20 0.48
POLB P06746 3/20 0.48
TDP1 Q9NUW8 3/20 0.48
KDM4E B2RXH2 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
APEX1 P27695 1/20 0.48
ESR2 Q92731 1/20 0.48
LMNA P02545 4/20 0.47
MAPT P10636 3/20 0.47
TSHR P16473 2/20 0.47
HSD17B10 Q99714 2/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
ESR1 P03372 1/20 0.47
PKM P14618 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18998666 0.79 ALDH1A1 (0.53) NPC1ADORA2BALDH1A1POLBTDP1
SCHEMBL20614560 0.77 KDM4E (0.49) NPC1ADORA2BALDH1A1POLBTDP1
SCHEMBL11660644 0.75 TSHR (0.55) NPC1ALDH1A1KDM4EMAPTTSHR
SCHEMBL11660640 0.75 TSHR (0.55) NPC1ALDH1A1KDM4EMAPTTSHR
SCHEMBL27322396 0.73 ADORA2B (0.41) ADORA2BALDH1A1POLBTDP1KDM4E
SCHEMBL16708942 0.71 ESR2 (0.52) ALDH1A1POLBKDM4EESR2LMNA
SCHEMBL21065269 0.71 ESR2 (0.52) ALDH1A1POLBKDM4EESR2LMNA
SCHEMBL1298246 0.71 MAPT (0.50) ALDH1A1LMNAMAPTHSD17B10MEN1
SCHEMBL6736374 0.71 MAPT (0.50) ALDH1A1LMNAMAPTHSD17B10MEN1
SCHEMBL11661818 0.71 ALDH1A1 (0.45) NPC1ALDH1A1KDM4EL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291520-B1 INHIBIT THE ENZYME LIPOXYGENASE; TREATMENT OR ALLEVIATION OF INFLAMMATORY DISEASES, ALLERGIC CONDITIONS AND CARDIOVASCULAR DISEASES PFIZER 2001-09-18 US disclosed
CN-1029230-C Hydroxamic acid and N-hydroxyurea derivatives and their use PFIZER (US) 1995-07-05 CN disclosed
EP-0559743-B1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE PFIZER (US) 1995-03-08 EP disclosed
EP-0559743-A1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE. PFIZER HOSPITAL PROD (US) 1993-09-15 EP disclosed
WO-1992009566-A1 NOVEL HYDROXAMIC ACID AND N-HYDROXYUREA DERIVATIVES AND THEIR USE PFIZER INC. (US) 1992-06-11 WO disclosed
CN-1061775-A New hydroxamic acid and N-hydroxyl urea derivant and uses thereof PFIZER (US) 1992-06-10 CN disclosed