Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JUND | P17535 | 1/20 | 0.37 |
| ▸ | FOSB | P53539 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967205 | 0.78 | ALK (0.38) | HTR1AHTR2CJUNDFOSBSLC6A2 | |
| SCHEMBL7965946 | 0.74 | CDK1 (0.40) | MEN1KMT2AHTR1AHTR2CKCNH2 | |
| Hydrochloric Acid SCHEMBL29862880 | 0.74 | KMT2A (0.46) | MEN1KMT2AHTR2CHTR6NPC1 | |
| SCHEMBL7969679 | 0.71 | MEN1 (0.52) | MEN1KMT2AHTR1AHTR2CJUND | |
| SCHEMBL21000902 | 0.70 | MEN1 (0.57) | MEN1KMT2AHTR1AHTR2CSLC6A4 | |
| SCHEMBL29733200 | 0.70 | MEN1 (0.57) | MEN1KMT2AHTR1AHTR2CSLC6A4 | |
| SCHEMBL7955565 | 0.69 | BCHE (0.51) | HTR1AHTR2CJUNDFOSBSLC6A2 | |
| SCHEMBL7965941 | 0.69 | PARP1 (0.54) | HTR2CJUNDFOSB | |
| SCHEMBL28191156 | 0.68 | MEN1 (0.40) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23858239 | 0.67 | HTR2C (0.40) | MEN1KMT2AHTR1AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |