Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | JUND | P17535 | 1/20 | 0.34 |
| ▸ | FOSB | P53539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967131 | 0.71 | JUND (0.38) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7967205 | 0.70 | ALK (0.38) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7970948 | 0.69 | MEN1 (0.41) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10901531 | 0.69 | BCHE (0.66) | BCHEACHEMAOBCA12CA1 | |
| SCHEMBL721717 | 0.68 | ACHE (1.00) | BCHEACHESLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL9937223 | 0.67 | ACHE (0.97) | BCHEACHEHTR2CSLC6A2SLC6A4 | |
| SCHEMBL10906155 | 0.67 | MAOA (0.56) | BCHEACHEHTR2CSLC6A2SLC6A4 | |
| SCHEMBL7967581 | 0.67 | GBA1 (0.35) | — | |
| SCHEMBL10902985 | 0.65 | ACHE (0.56) | BCHEACHEHTR2CMAOAMAOB | |
| SCHEMBL16283608 | 0.64 | CYP2A6 (0.68) | MAOACA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |