Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | JUND | P17535 | 1/20 | 0.36 |
| ▸ | FOSB | P53539 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963421 | 0.79 | MEN1 (0.60) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL28216138 | 0.79 | KMT2A (0.60) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL6172529 | 0.76 | ALDH1A1 (0.58) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL7964862 | 0.73 | JUND (0.39) | MEN1KMT2AHTR2CJUNDFOSB | |
| SCHEMBL7965941 | 0.73 | PARP1 (0.54) | ALDH1A1HTR2CMAPTJUNDFOSB | |
| SCHEMBL18364916 | 0.72 | ALDH1A1 (0.49) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL7970948 | 0.71 | MEN1 (0.41) | MEN1KMT2ARAB9ANPC1HTR2C | |
| SCHEMBL2710382 | 0.69 | KMT2A (1.00) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL18364919 | 0.69 | ALDH1A1 (0.49) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL7965946 | 0.68 | CDK1 (0.40) | MEN1KMT2AHTR2CJUNDFOSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |