Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3374076 | 0.88 | MEN1 (0.57) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL11157975 | 0.86 | MEN1 (0.62) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL2073208 | 0.86 | MAPT (0.65) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4907597 | 0.86 | LMNA (0.67) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL6311629 | 0.85 | MAPT (0.66) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL2075250 | 0.85 | ALDH1A1 (0.72) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4906987 | 0.84 | SMN1; SMN2 (0.53) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4905943 | 0.82 | POLB (0.62) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL31578670 | 0.81 | ALDH1A1 (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7973943 | 0.81 | RAB9A (0.66) | MEN1KMT2AMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |