Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.56 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.56 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.56 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976449 | 0.91 | USP30 (0.55) | GPR132CMKLR2CMKLR1CTSLCTSS | |
| SCHEMBL7973132 | 0.89 | TACR1 (0.61) | GPR132TACR1CTSLCTSBCTSS | |
| SCHEMBL8116271 | 0.85 | TACR1 (0.58) | GPR132CMKLR2CMKLR1ECE1TACR1 | |
| SCHEMBL7972845 | 0.82 | CYP3A4 (0.57) | GPR132CMKLR2CMKLR1ECE1TACR1 | |
| SCHEMBL7415738 | 0.80 | ECE1 (0.64) | GPR132CMKLR2CMKLR1ECE1CTSV | |
| SCHEMBL27520437 | 0.80 | ECE1 (0.64) | GPR132CMKLR2CMKLR1ECE1CTSV | |
| SCHEMBL7976251 | 0.80 | TACR1 (0.79) | ECE1TACR1CTSLCTSBCTSS | |
| SCHEMBL7978502 | 0.79 | HDAC3 (0.56) | GPR132CTSLCTSBCTSSPIN1 | |
| SCHEMBL15869689 | 0.79 | ECE1 (0.62) | GPR132CMKLR2CMKLR1ECE1CTSV | |
| SCHEMBL23489730 | 0.79 | ECE1 (0.65) | GPR132CMKLR2CMKLR1ECE1CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271247-B1 | BINDING TO NEUROPEPTIDE RECEPTORS | ADIR ET COMPAGNIE (FR) | 2001-08-07 | — | — | US | disclosed |
| US-6172108-B1 | NEUROPEPTIDE Y RECEPTOR LIGANDS; TREATING PSYCHOLOGICAL, EATING, SLEEP, AND SEXUAL DISORDERS; HYPOTENSIVE, ANXIOLYTIC, ANTIDEPRESSANT, AND ANTIDIABETIC AGENTS | ADIR ET COMPAGNIE (FR) | 2001-01-09 | — | — | US | disclosed |
| EP-1010691-A2 | Hydrazide derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |