Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 17/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 16/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957056 | 0.89 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BOPRM1ADRA2A | |
| SCHEMBL6782399 | 0.88 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6793226 | 0.85 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785443 | 0.83 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6785290 | 0.80 | ADRA1A (0.70) | ADRA1AADRA1DADRA1BOPRM1ADRA2A | |
| SCHEMBL6786014 | 0.80 | ADRA1A (0.59) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7242253 | 0.80 | ADRA1A (0.58) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6296632 | 0.80 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BOPRM1ADRA2A | |
| SCHEMBL7242551 | 0.79 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7967228 | 0.78 | ADRA1D (0.59) | ADRA1AADRA1DADRA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |
| WO-1996014846-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |