Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.52 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2546886 | 0.94 | RAB9A (0.52) | RAB9AKMT2AGAAMAPTRXFP1 | |
| SCHEMBL21489685 | 0.88 | SMYD3 (0.52) | RAB9AKMT2AGAAMLLT3MLLT1 | |
| SCHEMBL19710315 | 0.88 | SMYD3 (0.52) | RAB9AKMT2AGAAMLLT3MLLT1 | |
| SCHEMBL23575941 | 0.84 | SMYD3 (0.61) | — | |
| SCHEMBL19710202 | 0.84 | SMYD3 (0.61) | — | |
| SCHEMBL20460381 | 0.84 | RAB9A (0.44) | RAB9AKMT2AGAAMAPTRXFP1 | |
| SCHEMBL20460316 | 0.83 | ALOX15 (0.63) | RAB9AKMT2AGAAMAPTSMN1; SMN2 | |
| SCHEMBL6889670 | 0.82 | GAA (0.59) | RAB9AKMT2AGAAMAPTRXFP1 | |
| SCHEMBL21489903 | 0.81 | SMYD3 (0.48) | RAB9AKMT2AGAARXFP1LMNA | |
| SCHEMBL20460359 | 0.81 | ALOX15 (0.63) | RAB9AKMT2AGAAMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |