Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20460316 | 0.97 | ALOX15 (0.63) | ALOX15RAB9AL3MBTL1NPC1MAPT | |
| SCHEMBL13035843 | 0.81 | ALOX15 (0.73) | ALOX15 | |
| SCHEMBL6889670 | 0.81 | GAA (0.59) | RAB9ANPC1MAPTGAAKMT2A | |
| SCHEMBL7971605 | 0.81 | RAB9A (0.56) | RAB9ANPC1MAPTGAAKMT2A | |
| SCHEMBL6888967 | 0.81 | MAPT (0.57) | RAB9AL3MBTL1NPC1MAPTGAA | |
| SCHEMBL2073956 | 0.80 | ALOX15 (0.71) | ALOX15MAPTGAA | |
| SCHEMBL20460357 | 0.80 | ALOX15 (0.66) | ALOX15KMT2A | |
| SCHEMBL10144833 | 0.79 | ALOX15 (0.49) | ALOX15RAB9ANPC1MAPTKMT2A | |
| SCHEMBL23710419 | 0.79 | ALOX15 (0.64) | ALOX15RAB9A | |
| SCHEMBL20460301 | 0.79 | ALOX15 (0.64) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288351-B1 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2018-08-08 | — | — | EP | disclosed |