SCHEMBL7971622

SCHEMBL7971622

CC(C)(C)OC(=O)N(CCN)CCCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MC5R P33032 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.45
AOC3 Q16853 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
ALOX5 P09917 1/20 0.42
POLB P06746 1/20 0.41
LMNA P02545 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
KMT2A Q03164 1/20 0.41
MC4R P32245 1/20 0.41
MC3R P41968 1/20 0.41
MAOA P21397 1/20 0.41
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8583347 0.93 MAOA (0.47) MC5RL3MBTL1AOC3HDAC3HDAC1
SCHEMBL2260891 0.93 MEN1 (0.45) L3MBTL1AOC3HDAC3HDAC1HDAC2
SCHEMBL30940776 0.90 MC5R (0.46) MC5RL3MBTL1HDAC3HDAC1HDAC2
SCHEMBL1844315 0.87 L3MBTL1 (0.46) L3MBTL1AOC3HDAC3HDAC1HDAC2
SCHEMBL7983925 0.87 L3MBTL1 (0.46) L3MBTL1AOC3HDAC3HDAC1HDAC2
SCHEMBL7983626 0.86 L3MBTL1 (0.48) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL6400630 0.86 L3MBTL1 (0.47) L3MBTL1AOC3HDAC3HDAC1HDAC2
SCHEMBL1231760 0.86 HDAC3 (0.53) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL25046666 0.83 L3MBTL1 (0.45) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL25047708 0.83 HDAC3 (0.48) L3MBTL1HDAC3HDAC1HDAC2NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235731-B1 REDUCING BLOOD LIPIDS, SUGARS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0915888-A1 FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS Takeda Chemical Industries, Ltd. (JP) 1999-05-19 EP disclosed
WO-1997040051-A1 FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-30 WO disclosed