Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.69 |
| ▸ | MMP3 | P08254 | 2/20 | 0.69 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.68 |
| ▸ | CTSD | P07339 | 2/20 | 0.59 |
| ▸ | MGAM | O43451 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | SI | P14410 | 1/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971693 | 1.00 | MMP13 (0.69) | MMP13MMP3SIRT2CTSDMGAM | |
| SCHEMBL12892051 | 0.89 | ADAMTS5 (0.72) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7958747 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7958745 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7968308 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7971523 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7969940 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7969943 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7968305 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA | |
| SCHEMBL7971526 | 0.84 | MMP3 (0.71) | MMP13MMP3CTSDMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |