Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.60 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.52 |
| ▸ | CDK2 | P24941 | 8/20 | 0.52 |
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CCNH | P51946 | 1/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960337 | 0.94 | PRUNE1 (0.59) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL7970173 | 0.82 | TDP1 (0.54) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL7960318 | 0.81 | TP53 (0.46) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL3682526 | 0.79 | PRUNE1 (0.70) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL27221084 | 0.77 | CCNE2 (0.71) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL15619030 | 0.75 | CCNE2 (0.68) | PRUNE1CCNE2CCNE1CDK2CDK1 | |
| SCHEMBL17802610 | 0.73 | MAPT (0.47) | CCNE2CCNE1CDK2CDK1PDE10A | |
| SCHEMBL17802595 | 0.72 | MAPT (0.47) | CCNE2CCNE1CDK2CDK1PDE4D | |
| SCHEMBL3109840 | 0.72 | APP (0.65) | CLK4 | |
| SCHEMBL3682525 | 0.71 | PRUNE1 (0.67) | PRUNE1CCNE2CCNE1CDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297250-B1 | USEFUL FOR INHIBITING TRANSPORT OF NUCLEOSIDES OR PURINES ACROSS CELL MEMBRANES, THEREBY TO POTENTIATE THE ACTIVITY OF VARIOUS CYTOTOXIC ANTITUMOR DRUGS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-02 | — | — | US | disclosed |