Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968817 | 0.88 | RAB9A (0.52) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL158270 | 0.84 | RAB9A (0.68) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL865349 | 0.83 | RAB9A (0.71) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL30903806 | 0.82 | ALDH1A1 (0.54) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL498283 | 0.82 | MAOB (0.60) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOB | |
| SCHEMBL6187222 | 0.80 | RAB9A (0.62) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL1222314 | 0.80 | RAB9A (0.62) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL8422956 | 0.79 | NR4A2 (0.60) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOA | |
| SCHEMBL15774723 | 0.79 | ALDH1A1 (0.59) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOB | |
| SCHEMBL2168244 | 0.79 | TSHR (0.60) | RAB9ASMN1; SMN2ALDH1A1KDM4EMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |