Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.65 |
| ▸ | MMP13 | P45452 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MYC | P01106 | 1/20 | 0.64 |
| ▸ | MAX | P61244 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.60 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972211 | 1.00 | MMP3 (0.65) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL7958380 | 0.97 | MMP3 (0.66) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL7958378 | 0.97 | MMP3 (0.66) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL4053583 | 0.90 | MMP3 (0.71) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL4049839 | 0.90 | MMP3 (0.71) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL7971324 | 0.90 | ADAMTS5 (0.70) | MMP3MMP13ADAMTS5NAT1 | |
| SCHEMBL7971322 | 0.90 | ADAMTS5 (0.70) | MMP3MMP13ADAMTS5NAT1 | |
| SCHEMBL7968927 | 0.89 | MMP3 (0.69) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL7968931 | 0.89 | MMP3 (0.69) | MMP3MMP13RAB9ANPC1MYC | |
| SCHEMBL7968122 | 0.87 | MMP3 (0.72) | MMP3MMP13RAB9ANPC1MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |