SCHEMBL7972340

SCHEMBL7972340

COC(=O)C(Cc1ccc2c(c1)oc1ccccc12)NC(=O)C1(NC(=O)OC(C)(C)C)CCCC1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ECE1 P42892 10/20 0.44
KLK5 Q9Y337 1/20 0.43
MME P08473 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
EPHX2 P34913 1/20 0.39
KDR P35968 1/20 0.38
ATM Q13315 2/20 0.38
LCK P06239 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7962457 0.87 KLK5 (0.53) ECE1KLK5MMEMEN1KMT2A
SCHEMBL7962462 0.87 KLK5 (0.53) ECE1KLK5MMEMEN1KMT2A
SCHEMBL7978481 0.81 ECE1 (0.43) ECE1MMEMEN1KMT2AKDR
SCHEMBL7978479 0.81 ECE1 (0.43) ECE1MMEMEN1KMT2AKDR
SCHEMBL7976231 0.81 ECE1 (0.49) ECE1MMEMEN1KMT2AKDR
Hydrochloric Acid SCHEMBL7976234 0.81 ECE1 (0.48) ECE1MMEMEN1KMT2AKDR
SCHEMBL7223400 0.81 KLK5 (0.43) KLK5KMT2ALCK
Hydrochloric Acid SCHEMBL7976229 0.81 ECE1 (0.48) ECE1MMEMEN1KMT2AKDR
SCHEMBL8067917 0.80 NPSR1 (0.54) ECE1KLK5MEN1KMT2AKDR
SCHEMBL7223168 0.79 KLK5 (0.45) ECE1KLK5MEN1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001077095-A2 DERIVATIVES OF ALPHA-MERCAPTOACETAMIDE NOVARTIS AG (CH) 2001-10-18 WO disclosed