Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HEXA | P06865 | 2/20 | 0.34 |
| ▸ | HEXB | P07686 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131480 | 0.95 | HEXA (0.37) | MTNR1ANQO2MTNR1BHTR2CHEXA | |
| SCHEMBL7985052 | 0.83 | HEXA (0.50) | SLC2A1HEXAHEXB | |
| SCHEMBL7985064 | 0.82 | HEXA (0.52) | SLC2A1HEXAHEXB | |
| SCHEMBL7971372 | 0.81 | HEXA (0.51) | SLC2A1HEXAHEXB | |
| SCHEMBL7985741 | 0.81 | HEXA (0.46) | SLC2A1HEXAHEXB | |
| SCHEMBL7989141 | 0.78 | ALDH1A1 (0.44) | SLC2A1HEXAHEXBKMT2A | |
| SCHEMBL8122059 | 0.77 | HEXA (0.55) | HEXAHEXB | |
| SCHEMBL7982435 | 0.77 | NTRK1 (0.39) | MTNR1AMTNR1BKMT2A | |
| SCHEMBL8126116 | 0.77 | HEXA (0.54) | HEXAHEXB | |
| SCHEMBL8136088 | 0.76 | HEXA (0.49) | HEXAHEXB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300340-B1 | USEFUL FOR THERAPY OF CANCER AND SOLID TUMORS | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |